Product Name: TRIMETHOPRIM TMP

Characteristics

Appearance

White    or yellowish-white powder

White    powder

Solubility

Very    slightly soluble in water, slig

htly soluble in alcohol.

Very    slightly soluble in water, slightly soluble in alcohol.

Identification

A:    Melting point

199-203℃

199-200℃

B:Specific    absorbance

Max    .287nm:240-250

244

C:IR-spectrum

Complies    with reference spectrum

Complies    with reference spectrum

D: Chemical reaction

Green fluorescence at 365nm

Green fluorescence at 365nm

Appearance of solution

Not    more intensely colored than Reference Solution BY7

Less    intensely colored than Reference Solution BY7

Related substances

Method A by HPLC:
     Impurity F

≤0.1%

Not    detected

Any single impurity

≤0.1%

＜0.    1%

Total impurities

≤0.2%

＜0.2%

Method B by HPLC:
     Any single impurity

≤0.1%

＜0.1%

Total impurities

≤0.2%

＜0.2%

Heavy metals

≤20ppm

＜20ppm

Residual methanol

≤3000ppm

Not    detected

Residual    DMSO

≤5000ppm

Not    detected

Impurity    K (aniline) by  GC

≤5ppm

＜5ppm

Loss    on drying

≤1.0%

0.4%

Sulphated    ash

≤0.1%

0.02%

Assay

98.5-101.0%

99.3%