Specification:
| Items | Specifications |
Appearance | white to yellowish crystalline powder |
Solubility | Slightly soluble in water, freely soluble in 3 N hydrochloric acid; Slighty soluble in methanol, Practically insoluble in alcohol, in acetone, in Chloroform, and in ether |
Identification | A. IR: The spectrum of sample complies with the spectrum obtained with standard |
Specific rotation: | -21.0°~ -23.5° |
Heavy metal | Not more than 0.001% |
Residue on ignition: | Not more than 0.1% |
Methyldopa: | Not more than 0.5% |
Carbidopa related compound A: | Not more than 0.5% |
Any other impurity: | Not more than 0.1% |
Total impurities: | Not more than 1.0% |
Residual solvents: | Meets the requirements |
Assay: | 98.0% ~ 102.0% |
Application:
Captoril is used for the treatment of hypertension and heart failure. It is a synthetic non peptide angiotensin which converted to enzyme inhibitor, and it is mainly applied in the renin angiotensin aldosterone system (RAA system). Angiotensin of inhibiting the RAA system is converted to enzyme (ACE), which can block angiotensin I converted to angiotensin II, it can inhibit aldosterone secretion and reduce the retention of
water and sodium. It is used for treating high blood pressure, also used for ineffective treatment of diuretics, digitalis in patients with heart failure.
Packing:
25kg net composite paper-plastic bags or 3 ply-kraft paper bags with PE liner, 500kg or 1000kg net PP woven Jumbo bags or as customer required.
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